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Of Mice and not Humans: How Reliable are Animal Models for Evaluation of Herpes CD8(+)-T cell-Epitopes-Based Immunotherapeutic Vaccine Candidates?
Herpes simplex virus type 1 and type 2 (HSV-1 and HSV-2) -specific CD8(+) T cells that reside in sensory ganglia, appears to control recurrent herpetic disease by aborting or reducing spontaneous and sporadic reactivations of latent virus. A reliable animal model is the ultimate key factor to test t...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3159167/ https://ncbi.nlm.nih.gov/pubmed/21718746 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2011.06.083 |
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