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Of Mice and not Humans: How Reliable are Animal Models for Evaluation of Herpes CD8(+)-T cell-Epitopes-Based Immunotherapeutic Vaccine Candidates?

Herpes simplex virus type 1 and type 2 (HSV-1 and HSV-2) -specific CD8(+) T cells that reside in sensory ganglia, appears to control recurrent herpetic disease by aborting or reducing spontaneous and sporadic reactivations of latent virus. A reliable animal model is the ultimate key factor to test t...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Dasgupta, Gargi, BenMohamed, Lbachir
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159167/
https://ncbi.nlm.nih.gov/pubmed/21718746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2011.06.083
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