A Novel HLA (HLA-A*0201) Transgenic Rabbit Model for Preclinical Evaluation of Human CD8(+) T Cell Epitope-Based Vaccines against Ocular Herpes

We introduced a novel humanized HLA-A*0201 transgenic (HLA Tg) rabbit model to assess the protective efficacy of a human CD8(+) T cell epitope-based vaccine against primary ocular herpes infection and disease. Each of the three immunodominant human CD8(+) T cell peptide epitopes from HSV-1 glycoprot...

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Hauptverfasser: Chentoufi, Aziz A., Dasgupta, Gargi, Christensen, Neil D., Hu, Jiafen, Choudhury, Zareen S., Azeem, Arfan, Jester, James V., Nesburn, Anthony B., Wechsler, Steven L., BenMohamed, Lbachir
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752373/
https://ncbi.nlm.nih.gov/pubmed/20124097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902322
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