The Herpes Simplex Virus Latency-Associated Transcript Gene Is Associated with a Broader Repertoire of Virus-Specific Exhausted CD8(+) T Cells Retained within the Trigeminal Ganglia of Latently Infected HLA Transgenic Rabbits

Persistent pathogens, such as herpes simplex virus 1 (HSV-1), have evolved a variety of immune evasion strategies to avoid being detected and destroyed by the host's immune system. A dynamic cross talk appears to occur between the HSV-1 latency-associated transcript (LAT), the only viral gene t...

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Bibliographic Details
Published in:J Virol
Main Authors: Srivastava, Ruchi, Dervillez, Xavier, Khan, Arif A., Chentoufi, Aziz A., Chilukuri, Sravya, Shukr, Nora, Fazli, Yasmin, Ong, Nicolas N., Afifi, Rasha E., Osorio, Nelson, Geertsema, Roger, Nesburn, Anthony B., Wechsler, Steven L., BenMohamed, Lbachir
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810530/
https://ncbi.nlm.nih.gov/pubmed/26842468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02450-15
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