HLA-A02:01-Restricted Epitopes Identified from the Herpes Simplex Virus Tegument Protein VP11/12 Preferentially Recall Polyfunctional Effector Memory CD8(+) T Cells from Seropositive Asymptomatic Individuals and Protect “Humanized” HLA-A*02:01 Transgenic Mice Against Ocular Herpes

The Herpes Simplex Virus type 1 virion tegument phosphoprotein 11/12 (HSV-1 VP11/12) is a major antigen targeted by CD8(+) T cells from HSV-seropositive individuals. However, whether and which VP11/12-epitope-specific CD8(+) T cells play a role in the “natural” protection seen in seropositive health...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Srivastava, Ruchi, Khan, Arif A., Spencer, Doran, Vahed, Hawa, Lopes, Patricia P., Thai, Nhi Thi Uyen, Wang, Christine, Pham, Thanh T., Huang, Jiawei, Scarfone, Vanessa M., Nesburn, Anthony B., Wechsler, Steven L., BenMohamed, Lbachir
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340763/
https://ncbi.nlm.nih.gov/pubmed/25617474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402606
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