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HLA-A02:01-Restricted Epitopes Identified from the Herpes Simplex Virus Tegument Protein VP11/12 Preferentially Recall Polyfunctional Effector Memory CD8(+) T Cells from Seropositive Asymptomatic Individuals and Protect “Humanized” HLA-A*02:01 Transgenic Mice Against Ocular Herpes
The Herpes Simplex Virus type 1 virion tegument phosphoprotein 11/12 (HSV-1 VP11/12) is a major antigen targeted by CD8(+) T cells from HSV-seropositive individuals. However, whether and which VP11/12-epitope-specific CD8(+) T cells play a role in the “natural” protection seen in seropositive health...
Uloženo v:
| Vydáno v: | J Immunol |
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| Hlavní autoři: | , , , , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4340763/ https://ncbi.nlm.nih.gov/pubmed/25617474 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402606 |
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