Human Asymptomatic Epitopes Identified from the Herpes Simplex Virus Tegument Protein VP13/14 (UL47) Preferentially Recall Polyfunctional Effector Memory CD44(high) CD62L(low) CD8(+) T(EM) Cells and Protect Humanized HLA-A*02:01 Transgenic Mice against Ocular Herpesvirus Infection

Herpes simplex virus 1 (HSV-1) infection is widespread among humans. The HSV-1 virion protein 13/14 (VP13/14), also known as UL47, is a tegument antigen targeted by CD8(+) T cells from HSV-seropositive individuals. However, whether VP13/14-specific CD8(+) T cells play a role in the natural protectio...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Srivastava, Ruchi, Khan, Arif A., Garg, Sumit, Syed, Sabrina A., Furness, Julie N., Vahed, Hawa, Pham, Tiffany, Yu, Howard T., Nesburn, Anthony B., BenMohamed, Lbachir
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215341/
https://ncbi.nlm.nih.gov/pubmed/27847359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01793-16
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