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Human Asymptomatic Epitopes Identified from the Herpes Simplex Virus Tegument Protein VP13/14 (UL47) Preferentially Recall Polyfunctional Effector Memory CD44(high) CD62L(low) CD8(+) T(EM) Cells and Protect Humanized HLA-A*02:01 Transgenic Mice against Ocular Herpesvirus Infection
Herpes simplex virus 1 (HSV-1) infection is widespread among humans. The HSV-1 virion protein 13/14 (VP13/14), also known as UL47, is a tegument antigen targeted by CD8(+) T cells from HSV-seropositive individuals. However, whether VP13/14-specific CD8(+) T cells play a role in the natural protectio...
Zapisane w:
| Wydane w: | J Virol |
|---|---|
| Główni autorzy: | , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Microbiology
2017
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5215341/ https://ncbi.nlm.nih.gov/pubmed/27847359 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01793-16 |
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