Human Epitopes Identified from Herpes Simplex Virus Tegument Protein VP11/12 (UL46) Recall Multifunctional Effector Memory CD4(+) T(EM) Cells in Asymptomatic Individuals and Protect from Ocular Herpes Infection and Disease in “Humanized” HLA-DR Transgenic Mice

While the role of CD8(+) T cells in the control of herpes simplex virus 1 (HSV-1) infection and disease is gaining wider acceptance, a direct involvement of effector CD4(+) T cells in this protection and the phenotype and function of HSV-specific human CD4(+) T cell epitopes remain to be fully eluci...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Srivastava, Ruchi, Coulon, Pierre-Gregoire A., Prakash, Swayam, Dhanushkodi, Nisha R., Roy, Soumyabrata, Nguyen, Angela M., Alomari, Nuha I., Mai, Uyen T., Amezquita, Cassendra, Ye, Caitlin, Maillère, Bernard, BenMohamed, Lbachir
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Cellular Response to Infection
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7081904/
https://ncbi.nlm.nih.gov/pubmed/31915285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01991-19
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