Blockade of PD-1 and LAG-3 Immune Checkpoints Combined with Vaccination Restores the Function of Antiviral Tissue-Resident CD8(+) T(RM) Cells and Reduces Ocular Herpes Simplex Infection and Disease in HLA Transgenic Rabbits

Chronic viruses such as herpes simplex virus 1 (HSV-1) evade the hosts’ immune system by inducing the exhaustion of antiviral T cells. In the present study, we found that exhausted HSV-specific CD8(+) T cells, with elevated expression of programmed death ligand-1 (PD-1) and lymphocyte activation gen...

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Vydáno v:J Virol
Hlavní autoři: Roy, Soumyabrata, Coulon, Pierre-Gregoire, Prakash, Swayam, Srivastava, Ruchi, Geertsema, Roger, Dhanushkodi, Nisha, Lam, Cynthia, Nguyen, Vivianna, Gorospe, Elyssa, Nguyen, Angela M., Salazar, Stephanie, Alomari, Nuha I., Warsi, Wasay R., BenMohamed, Lbachir
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2019
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6714801/
https://ncbi.nlm.nih.gov/pubmed/31217250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00827-19
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