Asymptomatic HLA-A*02:01–Restricted Epitopes from Herpes Simplex Virus Glycoprotein B Preferentially Recall Polyfunctional CD8(+) T Cells from Seropositive Asymptomatic Individuals and Protect HLA Transgenic Mice against Ocular Herpes

Evidence from C57BL/6 mice suggests that CD8(+) T cells, specific to the immunodominant HSV-1 glycoprotein B (gB) H-2(b)–restricted epitope (gB(498–505)), protect against ocular herpes infection and disease. However, the possible role of CD8(+) T cells, specific to HLA-restricted gB epitopes, in pro...

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Auteurs principaux: Dervillez, Xavier, Qureshi, Huma, Chentoufi, Aziz A., Khan, Arif A., Kritzer, Elizabeth, Yu, David C., Diaz, Oscar R., Gottimukkala, Chetan, Kalantari, Mina, Villacres, Maria C., Scarfone, Vanessa M., McKinney, Denise M., Sidney, John, Sette, Alessandro, Nesburn, Anthony B., Wechsler, Steven L., BenMohamed, Lbachir
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4057607/
https://ncbi.nlm.nih.gov/pubmed/24101547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301415
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