Methotrexate prevents wear particle-induced inflammatory osteolysis via activation of the adenosine A(2A) receptor

OBJECTIVE: Adenosine, acting at A(2A)R, mediates the anti-inflammatory effects of methotrexate (MTX) in models of inflammation. We have previously reported that A(2A)R ligation diminishes wear particle-driven osteolysis and therefore asked whether MTX treatment could prevent bone resorption due to i...

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Bibliografiska uppgifter
I publikationen:Arthritis Rheumatol
Huvudupphovsmän: Mediero, Aránzazu, Perez-Aso, Miguel, Wilder, Tuere, Cronstein, Bruce N.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476949/
https://ncbi.nlm.nih.gov/pubmed/25533750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.38971
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