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Methotrexate prevents wear particle-induced inflammatory osteolysis via activation of the adenosine A(2A) receptor
OBJECTIVE: Adenosine, acting at A(2A)R, mediates the anti-inflammatory effects of methotrexate (MTX) in models of inflammation. We have previously reported that A(2A)R ligation diminishes wear particle-driven osteolysis and therefore asked whether MTX treatment could prevent bone resorption due to i...
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| Publicado no: | Arthritis Rheumatol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4476949/ https://ncbi.nlm.nih.gov/pubmed/25533750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.38971 |
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