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Activation of adenosine A(2A) receptor reduces osteoclast formation via PKA- and ERK1/2-mediated suppression of NFκB nuclear translocation

BACKGROUND AND PURPOSE: We previously reported that adenosine, acting at adenosine A(2A) receptors (A(2A)R), inhibits osteoclast (OC) differentiation in vitro (A(2A)R activation OC formation reduces by half) and in vivo. For a better understanding how adenosine A(2A)R stimulation regulates OC differ...

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Bibliografske podrobnosti
Main Authors: Mediero, Aránzazu, Perez-Aso, Miguel, Cronstein, Bruce N
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Publishing Ltd 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3831714/
https://ncbi.nlm.nih.gov/pubmed/23647065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12227
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