Netrin1 Is Highly Expressed And Required In Inflammatory Infiltrates In Wear Particle-Induced Osteolysis

OBJECTIVE: Netrin-1 is a chemorepulsant and matrix protein expressed during and required for osteoclast differentiation, which also plays a role in inflammation by preventing macrophage egress. Because wear particle-induced osteolysis requires osteoclast-mediated destruction of bone, we hypothesized...

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Bibliografiske detaljer
Udgivet i:Ann Rheum Dis
Main Authors: Mediero, Aránzazu, Ramkhelawon, Bhama, Wilder, Tuere, Purdue, P. Edward, Goldring, Steven R., Dewan, Zahidunnabi, Loomis, Cynthia, Moore, Kathryn J., Cronstein, Bruce N.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5349296/
https://ncbi.nlm.nih.gov/pubmed/26452536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2015-207593
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