The antiviral drug tenofovir, an inhibitor of Pannexin-1-mediated ATP release, prevents liver and skin fibrosis by downregulating adenosine levels in the liver and skin

BACKGROUND: Fibrosing diseases are a leading cause of morbidity and mortality worldwide and, therefore, there is a need for safe and effective antifibrotic therapies. Adenosine, generated extracellularly by the dephosphorylation of adenine nucleotides, ligates specific receptors which play a critica...

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Pubblicato in:PLoS One
Autori principali: Feig, Jessica L., Mediero, Aranzazu, Corciulo, Carmen, Liu, Hailing, Zhang, Jin, Perez-Aso, Miguel, Picard, Laura, Wilder, Tuere, Cronstein, Bruce
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5690602/
https://ncbi.nlm.nih.gov/pubmed/29145453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0188135
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