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Blocking PirB up-regulates spines and functional synapses to unlock visual cortical plasticity and facilitate recovery from amblyopia

During critical periods of development, the brain easily changes in response to environmental stimuli, but this neural plasticity declines by adulthood. By acutely disrupting paired immunoglobulin-like receptor B(PirB) function at specific ages, we show that PirB actively represses neural plasticity...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Sci Transl Med
Main Authors: Bochner, David N., Sapp, Richard W., Adelson, Jaimie D., Zhang, Siyu, Lee, Hanmi, Djurisic, Maja, Syken, Josh, Dan, Yang, Shatz, Carla J.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476552/
https://ncbi.nlm.nih.gov/pubmed/25320232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3010157
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