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Blocking PirB up-regulates spines and functional synapses to unlock visual cortical plasticity and facilitate recovery from amblyopia

During critical periods of development, the brain easily changes in response to environmental stimuli, but this neural plasticity declines by adulthood. By acutely disrupting paired immunoglobulin-like receptor B(PirB) function at specific ages, we show that PirB actively represses neural plasticity...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Bochner, David N., Sapp, Richard W., Adelson, Jaimie D., Zhang, Siyu, Lee, Hanmi, Djurisic, Maja, Syken, Josh, Dan, Yang, Shatz, Carla J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476552/
https://ncbi.nlm.nih.gov/pubmed/25320232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3010157
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