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Blocking PirB up-regulates spines and functional synapses to unlock visual cortical plasticity and facilitate recovery from amblyopia

During critical periods of development, the brain easily changes in response to environmental stimuli, but this neural plasticity declines by adulthood. By acutely disrupting paired immunoglobulin-like receptor B(PirB) function at specific ages, we show that PirB actively represses neural plasticity...

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Podrobná bibliografie
Vydáno v:Sci Transl Med
Hlavní autoři: Bochner, David N., Sapp, Richard W., Adelson, Jaimie D., Zhang, Siyu, Lee, Hanmi, Djurisic, Maja, Syken, Josh, Dan, Yang, Shatz, Carla J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476552/
https://ncbi.nlm.nih.gov/pubmed/25320232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3010157
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