Elafin Reverses Pulmonary Hypertension via Caveolin-1–Dependent Bone Morphogenetic Protein Signaling

Rationale: Pulmonary arterial hypertension is characterized by endothelial dysfunction, impaired bone morphogenetic protein receptor 2 (BMPR2) signaling, and increased elastase activity. Synthetic elastase inhibitors reverse experimental pulmonary hypertension but cause hepatotoxicity in clinical st...

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Detalhes bibliográficos
Publicado no:Am J Respir Crit Care Med
Main Authors: Nickel, Nils P., Spiekerkoetter, Edda, Gu, Mingxia, Li, Caiyun G., Li, Hai, Kaschwich, Mark, Diebold, Isabel, Hennigs, Jan K., Kim, Ki-Yoon, Miyagawa, Kazuya, Wang, Lingli, Cao, Aiqin, Sa, Silin, Jiang, Xinguo, Stockstill, Raymond W., Nicolls, Mark R., Zamanian, Roham T., Bland, Richard D., Rabinovitch, Marlene
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476518/
https://ncbi.nlm.nih.gov/pubmed/25853696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201412-2291OC
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