Elafin Treatment Rescues EGFR-Klf4 Signaling and Lung Cell Survival in Ventilated Newborn Mice

Mechanical ventilation with O(2)-rich gas (MV-O(2)) inhibits alveologenesis and lung growth. We previously showed that MV-O(2) increased elastase activity and apoptosis in lungs of newborn mice, whereas elastase inhibition by elafin suppressed apoptosis and enabled lung growth. Pilot studies suggest...

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Detalhes bibliográficos
Publicado no:Am J Respir Cell Mol Biol
Main Authors: Alejandre Alcazar, Miguel A., Kaschwich, Mark, Ertsey, Robert, Preuss, Stefanie, Milla, Carlos, Mujahid, Sana, Masumi, Juliet, Khan, Suleman, Mokres, Lucia M., Tian, Lu, Mohr, Jasmine, Hirani, Dharmesh V., Rabinovitch, Marlene, Bland, Richard D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6236693/
https://ncbi.nlm.nih.gov/pubmed/29894205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2017-0332OC
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