Elafin Treatment Rescues EGFR-Klf4 Signaling and Lung Cell Survival in Ventilated Newborn Mice

Mechanical ventilation with O(2)-rich gas (MV-O(2)) inhibits alveologenesis and lung growth. We previously showed that MV-O(2) increased elastase activity and apoptosis in lungs of newborn mice, whereas elastase inhibition by elafin suppressed apoptosis and enabled lung growth. Pilot studies suggest...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Am J Respir Cell Mol Biol
Päätekijät: Alejandre Alcazar, Miguel A., Kaschwich, Mark, Ertsey, Robert, Preuss, Stefanie, Milla, Carlos, Mujahid, Sana, Masumi, Juliet, Khan, Suleman, Mokres, Lucia M., Tian, Lu, Mohr, Jasmine, Hirani, Dharmesh V., Rabinovitch, Marlene, Bland, Richard D.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Thoracic Society 2018
Aiheet:
Original Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6236693/
https://ncbi.nlm.nih.gov/pubmed/29894205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2017-0332OC
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