Elafin Treatment Rescues EGFR-Klf4 Signaling and Lung Cell Survival in Ventilated Newborn Mice

Mechanical ventilation with O(2)-rich gas (MV-O(2)) inhibits alveologenesis and lung growth. We previously showed that MV-O(2) increased elastase activity and apoptosis in lungs of newborn mice, whereas elastase inhibition by elafin suppressed apoptosis and enabled lung growth. Pilot studies suggest...

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Bibliographic Details
Published in:Am J Respir Cell Mol Biol
Main Authors: Alejandre Alcazar, Miguel A., Kaschwich, Mark, Ertsey, Robert, Preuss, Stefanie, Milla, Carlos, Mujahid, Sana, Masumi, Juliet, Khan, Suleman, Mokres, Lucia M., Tian, Lu, Mohr, Jasmine, Hirani, Dharmesh V., Rabinovitch, Marlene, Bland, Richard D.
Format: Artigo
Language:Inglês
Published: American Thoracic Society 2018
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6236693/
https://ncbi.nlm.nih.gov/pubmed/29894205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2017-0332OC
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