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Elafin Treatment Rescues EGFR-Klf4 Signaling and Lung Cell Survival in Ventilated Newborn Mice
Mechanical ventilation with O(2)-rich gas (MV-O(2)) inhibits alveologenesis and lung growth. We previously showed that MV-O(2) increased elastase activity and apoptosis in lungs of newborn mice, whereas elastase inhibition by elafin suppressed apoptosis and enabled lung growth. Pilot studies suggest...
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| Udgivet i: | Am J Respir Cell Mol Biol |
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| Main Authors: | , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Thoracic Society
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6236693/ https://ncbi.nlm.nih.gov/pubmed/29894205 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2017-0332OC |
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