Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice.

Eitemau Tebyg

• Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton.
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• Identification of Ras farnesyltransferase inhibitors by microbial screening.
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  Cyhoeddwyd: (1993)
• Plant farnesyltransferase can restore yeast Ras signaling and mating.
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  Cyhoeddwyd: (1997)
• Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity.
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  Cyhoeddwyd: (1995)
• Ras farnesyltransferase inhibitors suppress the phenotype resulting from an activated ras mutation in Caenorhabditis elegans.
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  Cyhoeddwyd: (1995)