Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice.

The posttranslational addition of a farnesyl moiety to the Ras oncoprotein is essential for its transforming activity. Cell-active inhibitors of the enzyme that catalyzes this reaction, protein farnesyltransferase, have been shown to selectively block ras-dependent transformation of cells in culture...

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Bibliographic Details

Published in:	Proc Natl Acad Sci U S A
Main Authors:	Kohl, N E, Wilson, F R, Mosser, S D, Giuliani, E, deSolms, S J, Conner, M W, Anthony, N J, Holtz, W J, Gomez, R P, Lee, T J
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 1994
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44763/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8090782/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.19.9141
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