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Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice.
The posttranslational addition of a farnesyl moiety to the Ras oncoprotein is essential for its transforming activity. Cell-active inhibitors of the enzyme that catalyzes this reaction, protein farnesyltransferase, have been shown to selectively block ras-dependent transformation of cells in culture...
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| Main Authors: | , , , , , , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
1994
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC44763/ https://ncbi.nlm.nih.gov/pubmed/8090782 |
| Clibeanna: |
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