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Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice.

The posttranslational addition of a farnesyl moiety to the Ras oncoprotein is essential for its transforming activity. Cell-active inhibitors of the enzyme that catalyzes this reaction, protein farnesyltransferase, have been shown to selectively block ras-dependent transformation of cells in culture...

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Sonraí Bibleagrafaíochta
Main Authors: Kohl, N E, Wilson, F R, Mosser, S D, Giuliani, E, deSolms, S J, Conner, M W, Anthony, N J, Holtz, W J, Gomez, R P, Lee, T J
Formáid: Artigo
Teanga:Inglês
Foilsithe: 1994
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC44763/
https://ncbi.nlm.nih.gov/pubmed/8090782
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