Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice.
The posttranslational addition of a farnesyl moiety to the Ras oncoprotein is essential for its transforming activity. Cell-active inhibitors of the enzyme that catalyzes this reaction, protein farnesyltransferase, have been shown to selectively block ras-dependent transformation of cells in culture...
Kaydedildi:
| Yayımlandı: | Proc Natl Acad Sci U S A |
|---|---|
| Asıl Yazarlar: | , , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
National Academy of Sciences
1994
|
| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44763/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8090782/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.19.9141 |
| Etiketler: |
Etiket eklenmemiş, İlk siz ekleyin!
|