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Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity.

Small-molecule inhibitors of the housekeeping enzyme farnesyltransferase (FT) suppress the malignant growth of Ras-transformed cells. Previous work suggested that the activity of these compounds reflected effects on actin stress fiber regulation rather than Ras inhibition. Rho proteins regulate stre...

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Bibliografski detalji
Glavni autori: Lebowitz, P F, Davide, J P, Prendergast, G C
Format: Artigo
Jezik:Inglês
Izdano: 1995
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC230914/
https://ncbi.nlm.nih.gov/pubmed/8524226
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