Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity.
Small-molecule inhibitors of the housekeeping enzyme farnesyltransferase (FT) suppress the malignant growth of Ras-transformed cells. Previous work suggested that the activity of these compounds reflected effects on actin stress fiber regulation rather than Ras inhibition. Rho proteins regulate stre...
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| Publicado no: | Mol Cell Biol |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
1995
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230914/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8524226/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.12.6613 |
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