Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity.

Small-molecule inhibitors of the housekeeping enzyme farnesyltransferase (FT) suppress the malignant growth of Ras-transformed cells. Previous work suggested that the activity of these compounds reflected effects on actin stress fiber regulation rather than Ras inhibition. Rho proteins regulate stre...

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Publicado en:	Mol Cell Biol
Autores principales:	Lebowitz, P F, Davide, J P, Prendergast, G C
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis 1995
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230914/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8524226/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.12.6613
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