Identification of Ras farnesyltransferase inhibitors by microbial screening.

A microbial screen using a yeast strain with conditional deficiency in the GPA1 gene was carried out to search for inhibitors of protein farnesyltransferase (PFT). A strain of Streptomyces was found to produce active compounds named UCF1-A, UCF1-B, and UCF1-C. Structural determination of these compo...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Hara, M, Akasaka, K, Akinaga, S, Okabe, M, Nakano, H, Gomez, R, Wood, D, Uh, M, Tamanoi, F
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1993
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46070/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8460134/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.6.2281
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