Identification of Ras farnesyltransferase inhibitors by microbial screening.
A microbial screen using a yeast strain with conditional deficiency in the GPA1 gene was carried out to search for inhibitors of protein farnesyltransferase (PFT). A strain of Streptomyces was found to produce active compounds named UCF1-A, UCF1-B, and UCF1-C. Structural determination of these compo...
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| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
1993
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46070/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8460134/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.6.2281 |
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