Identification of Ras farnesyltransferase inhibitors by microbial screening.

A microbial screen using a yeast strain with conditional deficiency in the GPA1 gene was carried out to search for inhibitors of protein farnesyltransferase (PFT). A strain of Streptomyces was found to produce active compounds named UCF1-A, UCF1-B, and UCF1-C. Structural determination of these compo...

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Bibliographic Details
Main Authors: Hara, M, Akasaka, K, Akinaga, S, Okabe, M, Nakano, H, Gomez, R, Wood, D, Uh, M, Tamanoi, F
Format: Artigo
Language:Inglês
Published: 1993
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC46070/
https://ncbi.nlm.nih.gov/pubmed/8460134
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