Identification of Ras farnesyltransferase inhibitors by microbial screening.
A microbial screen using a yeast strain with conditional deficiency in the GPA1 gene was carried out to search for inhibitors of protein farnesyltransferase (PFT). A strain of Streptomyces was found to produce active compounds named UCF1-A, UCF1-B, and UCF1-C. Structural determination of these compo...
محفوظ في:
| الحاوية / القاعدة: | Proc Natl Acad Sci U S A |
|---|---|
| المؤلفون الرئيسيون: | , , , , , , , , |
| التنسيق: | Artigo |
| اللغة: | Inglês |
| منشور في: |
National Academy of Sciences
1993
|
| الموضوعات: | |
| الوصول للمادة أونلاين: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46070/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8460134/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.6.2281 |
| الوسوم: |
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|