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N-terminally extended analogues of ShK as potent and selective blockers of the voltage-gated potassium channel Kv1.3
The voltage-gated potassium channel Kv1.3 is an important target for the treatment of autoimmune diseases and asthma. Blockade of Kv1.3 by the sea anemone peptide ShK inhibits the proliferation of effector memory T lymphocytes and ameliorates autoimmune diseases in animal models. However, the lack o...
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| Опубликовано в: : | FEBS J |
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| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4472561/ https://ncbi.nlm.nih.gov/pubmed/25864722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.13294 |
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