Efficacy, but not antibody titer or affinity, of a heroin hapten conjugate vaccine correlates with increasing hapten densities on tetanus toxoid, but not on CRM(197) carriers

Vaccines against drugs of abuse have induced antibodies in animals that blocked the biological effects of the drug by sequestering the drug in the blood and preventing it from crossing the blood-brain barrier. Drugs of abuse are too small to induce antibodies and, therefore, require conjugation of d...

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Dades bibliogràfiques
Publicat a:Bioconjug Chem
Autors principals: Jalah, Rashmi, Torres, Oscar B., Mayorov, Alexander V., Li, Fuying, Antoline, Joshua F. G., Jacobson, Arthur E., Rice, Kenner C., Deschamps, Jeffrey R., Beck, Zoltan, Alving, Carl R., Matyas, Gary R.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4472500/
https://ncbi.nlm.nih.gov/pubmed/25970207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.5b00085
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