A Stable Heroin Analogue That Can Serve as a Vaccine Hapten to Induce Antibodies That Block the Effects of Heroin and Its Metabolites in Rodents and That Cross-React Immunologically with Related Drugs of Abuse

[Image: see text] An improved synthesis of a haptenic heroin surrogate 1 (6-AmHap) is reported. The intermediate needed for the preparation of 1 was described in the route in the synthesis of 2 (DiAmHap). A scalable procedure was developed to install the C-3 amido group. Using the Boc protectng grou...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Sulima, Agnieszka, Jalah, Rashmi, Antoline, Joshua F. G., Torres, Oscar B., Imler, Gregory H., Deschamps, Jeffrey R., Beck, Zoltan, Alving, Carl R., Jacobson, Arthur E., Rice, Kenner C., Matyas, Gary R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767880/
https://ncbi.nlm.nih.gov/pubmed/29236495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01427
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