Synthesis and immunological effects of heroin vaccines containing haptens with improved stability

Three haptens have been synthesized with linkers for attachment to carrier macromolecules at either the piperidino-nitrogen or via an introduced 3-amino group. Two of the haptens, with a 2-oxopropyl functionality at either C6, or at both the C3 and C6 positions on the 4,5-epoxymorphinan framework, a...

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Detalhes bibliográficos
Main Authors: Li, Fuying, Cheng, Kejun, Antoline, Joshua F. G., Iyer, Malliga R., Matyas, Gary R., Torres, Oscar B., Jalah, Rashmi, Beck, Zoltan, Alving, Carl R., Parrish, Damon A., Deschamps, Jeffrey R., Jacobson, Arthur E., Rice, Kenner C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4146676/
https://ncbi.nlm.nih.gov/pubmed/24995943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4ob01053a
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