Efficacy, but not antibody titer or affinity, of a heroin hapten conjugate vaccine correlates with increasing hapten densities on tetanus toxoid, but not on CRM(197) carriers

Vaccines against drugs of abuse have induced antibodies in animals that blocked the biological effects of the drug by sequestering the drug in the blood and preventing it from crossing the blood-brain barrier. Drugs of abuse are too small to induce antibodies and, therefore, require conjugation of d...

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Veröffentlicht in:Bioconjug Chem
Hauptverfasser: Jalah, Rashmi, Torres, Oscar B., Mayorov, Alexander V., Li, Fuying, Antoline, Joshua F. G., Jacobson, Arthur E., Rice, Kenner C., Deschamps, Jeffrey R., Beck, Zoltan, Alving, Carl R., Matyas, Gary R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4472500/
https://ncbi.nlm.nih.gov/pubmed/25970207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.5b00085
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