Efficacy, but not antibody titer or affinity, of a heroin hapten conjugate vaccine correlates with increasing hapten densities on tetanus toxoid, but not on CRM(197) carriers

Vaccines against drugs of abuse have induced antibodies in animals that blocked the biological effects of the drug by sequestering the drug in the blood and preventing it from crossing the blood-brain barrier. Drugs of abuse are too small to induce antibodies and, therefore, require conjugation of d...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Bioconjug Chem
Prif Awduron: Jalah, Rashmi, Torres, Oscar B., Mayorov, Alexander V., Li, Fuying, Antoline, Joshua F. G., Jacobson, Arthur E., Rice, Kenner C., Deschamps, Jeffrey R., Beck, Zoltan, Alving, Carl R., Matyas, Gary R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4472500/
https://ncbi.nlm.nih.gov/pubmed/25970207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.5b00085
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