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Efficacy, but not antibody titer or affinity, of a heroin hapten conjugate vaccine correlates with increasing hapten densities on tetanus toxoid, but not on CRM(197) carriers

Vaccines against drugs of abuse have induced antibodies in animals that blocked the biological effects of the drug by sequestering the drug in the blood and preventing it from crossing the blood-brain barrier. Drugs of abuse are too small to induce antibodies and, therefore, require conjugation of d...

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Bibliografiske detaljer
Udgivet i:Bioconjug Chem
Main Authors: Jalah, Rashmi, Torres, Oscar B., Mayorov, Alexander V., Li, Fuying, Antoline, Joshua F. G., Jacobson, Arthur E., Rice, Kenner C., Deschamps, Jeffrey R., Beck, Zoltan, Alving, Carl R., Matyas, Gary R.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4472500/
https://ncbi.nlm.nih.gov/pubmed/25970207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.5b00085
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