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LRP6 in mesenchymal stem cells is required for bone formation during bone growth and bone remodeling

Lipoprotein receptor-related protein 6 (LRP6) plays a critical role in skeletal development and homeostasis in adults. However, the role of LRP6 in mesenchymal stem cells (MSCs), skeletal stem cells that give rise to osteoblastic lineage, is unknown. In this study, we generated mice lacking LRP6 exp...

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Detalhes bibliográficos
Publicado no:Bone Res
Main Authors: Li, Changjun, Williams, Bart O, Cao, Xu, Wan, Mei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4472141/
https://ncbi.nlm.nih.gov/pubmed/26273519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/boneres.2014.6
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