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Where Wnts Went: The Exploding Field of Lrp5 and Lrp6 Signaling in Bone

Wnt signaling has emerged as a central regulator of skeletal modeling and remodeling. Loss- or gain-of-function mutations in two Wnt co-receptors, Lrp5 and (more recently) Lrp6, have drawn attention to the importance of the Wnt pathway in bone biology. This review summarizes our current understandin...

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Hlavní autoři: Williams, Bart O, Insogna, Karl L
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons and The American Society for Bone and Mineral Research (ASBMR) 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276354/
https://ncbi.nlm.nih.gov/pubmed/19072724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1359/jbmr.081235
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