Kinetic and structural basis for acyl-group selectivity and NAD(+)-dependence in Sirtuin-catalyzed deacylation

Acylation of lysine is an important protein modification regulating diverse biological processes. It was recently demonstrated that members of the human Sirtuin family are capable of catalyzing long-chain deacylation, in addition to the well-known NAD(+)-dependent deacetylation activity.(1) Here we...

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Detaylı Bibliyografya
Yayımlandı:Biochemistry
Asıl Yazarlar: Feldman, Jessica L., Dittenhafer-Reed, Kristin E., Kudo, Norio, Thelen, Julie N., Ito, Akihiro, Yoshida, Minoru, Denu, John M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4470489/
https://ncbi.nlm.nih.gov/pubmed/25897714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00150
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