Investigating the Sensitivity of NAD(+)-dependent Sirtuin Deacylation Activities to NADH

Protein lysine posttranslational modification by an increasing number of different acyl groups is becoming appreciated as a regulatory mechanism in cellular biology. Sirtuins are class III histone deacylases that use NAD(+) as a co-substrate during amide bond hydrolysis. Several studies have describ...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Madsen, Andreas S., Andersen, Christian, Daoud, Mohammad, Anderson, Kristin A., Laursen, Jonas S., Chakladar, Saswati, Huynh, Frank K., Colaço, Ana R., Backos, Donald S., Fristrup, Peter, Hirschey, Matthew D., Olsen, Christian A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807294/
https://ncbi.nlm.nih.gov/pubmed/26861872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.668699
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