Investigating the Sensitivity of NAD(+)-dependent Sirtuin Deacylation Activities to NADH

Protein lysine posttranslational modification by an increasing number of different acyl groups is becoming appreciated as a regulatory mechanism in cellular biology. Sirtuins are class III histone deacylases that use NAD(+) as a co-substrate during amide bond hydrolysis. Several studies have describ...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Madsen, Andreas S., Andersen, Christian, Daoud, Mohammad, Anderson, Kristin A., Laursen, Jonas S., Chakladar, Saswati, Huynh, Frank K., Colaço, Ana R., Backos, Donald S., Fristrup, Peter, Hirschey, Matthew D., Olsen, Christian A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Enzymology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807294/
https://ncbi.nlm.nih.gov/pubmed/26861872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.668699
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