Investigating the Sensitivity of NAD(+)-dependent Sirtuin Deacylation Activities to NADH

Protein lysine posttranslational modification by an increasing number of different acyl groups is becoming appreciated as a regulatory mechanism in cellular biology. Sirtuins are class III histone deacylases that use NAD(+) as a co-substrate during amide bond hydrolysis. Several studies have describ...

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Vydáno v:J Biol Chem
Hlavní autoři: Madsen, Andreas S., Andersen, Christian, Daoud, Mohammad, Anderson, Kristin A., Laursen, Jonas S., Chakladar, Saswati, Huynh, Frank K., Colaço, Ana R., Backos, Donald S., Fristrup, Peter, Hirschey, Matthew D., Olsen, Christian A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Enzymology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807294/
https://ncbi.nlm.nih.gov/pubmed/26861872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.668699
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