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Catalysis and mechanistic insights on Sirtuin activation

SIRT1 is a member of the Sir2 family of NAD(+) dependent protein deacetylases. The central role of SIRT1 in multiple metabolic and aging-related pathways has pushed SIRT1 to the forefront for the discovery of small molecule activators. Promising compounds including resveratrol and SRT1720 have been...

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Detalhes bibliográficos
Main Authors: Dittenhafer-Reed, Kristin E., Feldman, Jessica L., Denu, John M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3327882/
https://ncbi.nlm.nih.gov/pubmed/21243715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201000434
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