The Sheep as a Model of Preclinical Safety and Pharmacokinetic Evaluations of Candidate Microbicides

When developing novel microbicide products for the prevention of HIV infection, the preclinical safety program must evaluate not only the active pharmaceutical ingredient but also the product itself. To that end, we applied several relatively standard toxicology study methodologies to female sheep,...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Holt, Jonathon D. S., Cameron, David, Dias, Nicola, Holding, Jeremy, Muntendam, Alex, Oostebring, Freddy, Dreier, Peter, Rohan, Lisa, Nuttall, Jeremy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468677/
https://ncbi.nlm.nih.gov/pubmed/25845860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04954-14
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