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The Sheep as a Model of Preclinical Safety and Pharmacokinetic Evaluations of Candidate Microbicides

When developing novel microbicide products for the prevention of HIV infection, the preclinical safety program must evaluate not only the active pharmaceutical ingredient but also the product itself. To that end, we applied several relatively standard toxicology study methodologies to female sheep,...

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書誌詳細
出版年:Antimicrob Agents Chemother
主要な著者: Holt, Jonathon D. S., Cameron, David, Dias, Nicola, Holding, Jeremy, Muntendam, Alex, Oostebring, Freddy, Dreier, Peter, Rohan, Lisa, Nuttall, Jeremy
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468677/
https://ncbi.nlm.nih.gov/pubmed/25845860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04954-14
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