The Sheep as a Model of Preclinical Safety and Pharmacokinetic Evaluations of Candidate Microbicides

When developing novel microbicide products for the prevention of HIV infection, the preclinical safety program must evaluate not only the active pharmaceutical ingredient but also the product itself. To that end, we applied several relatively standard toxicology study methodologies to female sheep,...

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Bibliografiset tiedot
Julkaisussa:Antimicrob Agents Chemother
Päätekijät: Holt, Jonathon D. S., Cameron, David, Dias, Nicola, Holding, Jeremy, Muntendam, Alex, Oostebring, Freddy, Dreier, Peter, Rohan, Lisa, Nuttall, Jeremy
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2015
Aiheet:
Antiviral Agents
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468677/
https://ncbi.nlm.nih.gov/pubmed/25845860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04954-14
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