Pharmacokinetics of the Protein Microbicide 5P12-RANTES in Sheep following Single-Dose Vaginal Gel Administration

5P12-RANTES, a chemokine analogue that potently blocks the HIV CCR5 coreceptor, is being developed as both a vaginal and rectal microbicide for prevention of sexual transmission of HIV. Here, we report the first pharmacokinetic data for 5P12-RANTES following single-dose vaginal gel administration in...

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Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: McBride, John W., Dias, Nicola, Cameron, David, Offord, Robin E., Hartley, Oliver, Boyd, Peter, Kett, Vicky L., Malcolm, R. Karl
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2017
Sujets:
Antiviral Agents
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5610505/
https://ncbi.nlm.nih.gov/pubmed/28784672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00965-17
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