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Modified silicone elastomer vaginal gels for sustained release of antiretroviral HIV microbicides

We previously reported non-aqueous silicone elastomer gels (SEGs) for sustained vaginal administration of the CCR5-targeted entry inhibitor maraviroc. Here, we describe chemically modified SEGs (h-SEGs) in which the hydrophobic cyclomethicone component was partially replaced with relatively hydrophi...

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Detalhes bibliográficos
Main Authors: Forbes, Claire J., McCoy, Clare F., Murphy, Diarmaid J., Woolfson, A. David, Moore, John P., Evans, Abbey, Shattock, Robin J., Malcolm, R. Karl
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989844/
https://ncbi.nlm.nih.gov/pubmed/24585370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.23913
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